Alone and Forsaken
Joel and Ellie make it to Pittsburgh but the main road to the Fort Dusquene Bridge is blocked by rubble and derelict cars. Joel decides to go through the city rather than back up and detour around. While driving through the city Joel and Ellie see a person stumble into the middle of the street, begging for help. Ellie wants to stop and help, but Joel sees through the act and tries to speed past. The person, who had feigned his injuries, pulls out a gun and more men come out of hiding. One of them throws a brick at the truck, damaging the windshield. The Hunters push a bus into Joels truck, causing them to crash into a hardware store where they are forced to confront the Hunters. After eliminating the ambush group, the duo pass through their hideout and make their way to a long-abandoned military checkpoint. Along the way they discover that the military had been overthrown by the citizens who were now the Hunters. At the checkpoint the pair come across another group of hunters and stealthily made their way through the bookstore and into a back alley.
Hotel Lobby
Joel and Ellie escape the Hunters and make their way towards the bridge on the other side of the city. They come to the Hotel Grande and fight their way through until they come to an elevator shaft. Joel slips and falls down the shaft, leaving Ellie above. Joel finds a way out of the basement, running into a few infected along the way, including a Bloater. He has to start a generator to get a keycard door to function, attracting more Infected to him.
After escaping that, Joel tries to get back up to Ellie, but is attacked by a Hunter and almost killed. Ellie steps in at the last minute and kills the Hunter. Joel however does not show his gratitude, instead scolding her for not staying where she was, leading to an awkward silence between the pair. They get out of the hotel and head to the Financial District.

Financial District
Just outside the hotel, Joel spots a hunting rifle and another group of hunters. Joel plans to clear a path while Ellie stays behind in the scaffolding to cover for him with the rifle; teaching her how to use it a few minutes beforehand. Before he leaves, Joel subtly thanks her for saving him from the Hunter, reconciling their relationship.
Joel attempts to take out each hunter quickly and quietly but is soon discovered, prompting Ellie to snipe from her scaffolding. After all the hunters are dealt with, Joel gives Ellie a 9mm pistol, insisting that its "for emergencies only." The pair makes their way through the financial district though are spotted by the Humvee, commandeered by patrolling Hunters. The hunter crew immediately begin to give chase to Joel and Ellie. Using the debris and back streets as cover, the pair retreats into a building, seemingly losing the Humvee in the process.

Escape the CityEdit
As Joel enters a room using the outside ledge he is grabbed from behind by a black man. Ellie tries to help with her switchblade but is knocked aside. The man notices her and while he is distracted, Joel throws him off and pin him down. Ellie shouts out to stop, as they spot a boy pointing a gun at Joel. The man however tells the boy that it is alright, and introduces themselves as Henry and Sam, two brothers and survivors from another group. While Ellie thinks that they can help each other escape the city, Joel is not so trusting. The two pairs come to a mutual alliance and make their way to a hideout the brothers had holed up. Evading the Humvee and taking out more Hunters, they reach the hideout, is an office overlooking the Hunters' guard post to the bridge. Finding out that the pairs are both looking for the Fireflies, Henry tells Joel that his group of survivors had planned to meet up at an abandoned military radio station just outside of Pittsburgh by tomorrow night.
That night the four make their way out towards the guard post. After stealthily taking out two Hunters, Joel and Henry snuck towards the gate, avoiding the Hunters' searchlight as the snipers joyfully killed a Clicker while Ellie and Sam hung back. To distract them, Joel finds a generator powering the searchlight and turns it off, prompting them to hide as the Hunters investigated the source. Eventually a fight broke out leading Joel and Henry to kill the Hunters.

Afterwards the adults opened the gate, though not before the Humvee returns and spots them. Locking the gate to buy them time, the group tries to climb over a truck. Henry, Sam and Ellie made it on top but the ladder broke under Ellie's weight, leaving Joel stranded. As the Humvee prepared to bash the gate open, Henry abandoned Joel out of fear, followed by a reluctant Sam. Ellie returns to Joel's side as they retreat into a bar to avoid the Humvee's gunfire. After taking out the Hunters inside, Joel and Ellie run to the bridge, with the Humvee in pursuit. Blocked by the rubble and the large hole on the bridge, Joel attempts to make a last stand against the Humvee but Ellie bravely jumps into the river below, forcing Joel to follow. Joel reaches Ellie before she could drown, but the current slams the pair into a large rock and knocks them out.