Winning Combo
Throw a combined no-hitter with 2 or more pitchers (not achievable in RTTS; only earned if playing an uninterrupted 9-inning game against the CPU, without switching sides or fast forwarding).

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This seems to be a standard type of trophy every year. The only difference this time is that at some point in the game you must replace your starting pitcher with a reliever, so make sure you use your edited starting pitcher as well as an edited reliever. And naturally, you should be playing against a team that you edited for weak attributes. Adjust the following sliders to the max

Human Starter Stamina
Human Pitcher Control
Fielder Run Speed
Fielder Reaction
And then adjust the following to the minimum

CPU Contact
CPU Power
CPU Timing
CPU Solid Hits
Fielding Errors
Throwing Errors
Baserunner Speed
Another tip you can use that will help is to intentionally walk the lead-off man and allow him to attempt a stolen base and throw him out. You can get 6-7 outs this way across the game, giving the CPU less opportunities to break up your no-hitter. See Strike 'Em Out, Throw 'Em Out for more information about that.